Current Advances in the Treatment of Basal Cell Carcinoma

Basal cell carcinoma is the most commonly seen malignant tumor of the skin and its incidence is gradually increasing. Sun exposure is the single most important predisposing factor. In addition, genetic disorders, organ transplantations and immunesupression may trigger the development of basal cell carcinoma. Although it metastasizes rarely, its clinical course is local aggressive. The main treatment modality is surgery. In patients who are not candidates for surgery; radiotherapy, cryotherapy, chemotherapy and hedgehog pathway modulators can be used. In this review, current advances in the treatment of basal cell carcinoma is discussed.

Bazal Hücreli Karsinomun Tedavisinde Güncel Geliþmeler

Bazal hücreli karsinom, derinin en sýk görülen malign tümörü olup insidansý giderek artmaktadýr. Predispozan faktörler arasýnda en önemlisi güneþ ýþýnlarýna maruz kalmaktýr. Bununla birlikte genetik hastalýklar, organ nakilleri ve immünsupresyon da bazal hücreli karsinom geliþimini tetiklemektedir. Oldukça nadir metastaz yapmasýna raðmen lokal agresif seyreder. Ana tedavi þekli cerrahi olup cerrahiye aday olmayan hastalarda radyoterapi, kriyoterapi, kemoterapi ve hedgehog yolak inhibitörleri kullanýlabilir. Bu derlemede bazal hücreli karsinomun tedavisi konusunda güncel geliþmeler tartýþýlmýþtýr.